DermaPeptide Tanning PF
Preserved with Leucidal Liquid
FSS DermaPeptide Tanning PF is recommended for use in long-term tanning formulas.
It may be
used in conjunction with DHA products until the natural tanning simulation
It will help to generate eumelanin synthesis allowing
you to attain the richest, darkest, most even tan possible.
• Intended to optimize the tanning achieved with sunless
• Aides in creating a deeper more even tan for
a healthy glow.
It is thought that the trend of tanning was begun
accidently by Coco Chanel after a trip to the French Riviera in the 1920’s. To
this day being tan symbolizes a healthy, youthful appearance and consumers of
all ages strive to attain a rich, dark, even tan and keep it consistent all
year long. Lately, people have started to realize that along with this radiant
glow, there are detrimental effects caused by the UV rays that are necessary
for tanning. Therefore, consumers have been looking for a healthy way to keep
that summer look all year round.
the skin’s natural protection against the sun. It is the primary determinant of
human coloring and can be found in the hair, skin, and eyes. This molecule is
produced by melanocytes, which are found in the epidermis, or outer layer of
the skin. Melanin consists of two different types: Pheomelanin, which is a
yellow to reddish color, and eumelanin, which is generally black or brown.
melanogenic pathway for the production of eumelanin and pheomelanin both involve
a chain of enzymatic and non-enzymatic reactions with tyrosine playing a key
role. Eumelanin production begins with the enzymatic oxidation of L-tyrosine to
dopaquinone to form an intermediate called an indolic monomer, which is then
converted to eumelanin. Pheomelanin production begins when dopaquinone reacts
with cysteine to form the intermediate precursor called cysteinyldopa, which is
then converted into pheomelanin.
located in the basal lamina synthesize organelles called melanosomes that
contain melanin. Following synthesis, the melanosome is transferred to
keratinocytes. Keratinocytes that contain melanin granules then proceed along
the differentiation pathway, moving up through the epidermal layers until they
become part of the stratum corneum.
The melanocortin 1 receptor (MC1R), a melanocyte
surface receptor, may be an effective way to alter pigment production as
alpha-melanocyte stimulating hormone (a-MSH) has been shown to bind to the MC1R
and induce eumelanin production at the expense of pheomelanin production. In
contrast, the agouti signal protein (ASP) is capable of binding to the MC1R to
prevent the formation of eumelanin by inhibiting a-MSH and in turn stimulating
the production of pheomelanin. By using peptides that are capable of binding to
the MC1R, much like a-MSH and ASP, we may be able to alter melanin formation to
either enhance the production of one type of melanin while inhibiting the
production of the other.
Derived from Lactobacillus, FSS
DermaPeptide Tanning PF is intended to prevent pheomelanin synthesis while
simultaneously increasing eumelanin synthesis to induce a deep, dark, even tan.
The efficacy FSS DermaPeptide Tanning PF was first measured using an in-vitro
MatTek Melanoderm assay, which measures the amount of melanin content per
tissue as well as per tissue weight. Compared to the positive control, the results
demonstrate that FSS DermaPeptide Tanning PF is capable of stimulating
higher concentrations of visible melanin. The MTT assay was then performed to
determine any potential immunotoxic effects; fortunately the results indicate
that FSS DermaPeptide Tanning PF is safe for use in cosmetic and
personal care products.
Ferment Lysate Filtrate
Yellow Opaque Liquid
into cooling phase of your formula
Temperature Stability: <60°C
Storage: Protected from direct light and humidity at a temperature of
Shelf life: 12 months, properly stored, in sealed container. This
product should be added to a formulation at the recommended usage rate