FSS Dermal Respiratory Factor Advanced
Preserved with Leucidal Liquid
the work of Dr. George Sperti and the more recent working knowledge of the
yeast cell, we have developed a yeast derived extract for topical application,
FSS Dermal Respiratory Factor Advanced.
FSS Dermal Respiratory Factor Advanced is produced by prompting live yeast cells to secrete
synergistically active compounds, by striking the yeast cells with specific
wavelengths of UV radiation. Through the use of biofermentation and various
filtration techniques, such as tangential flow filtration, this secretion is
then isolated and extracted from the live yeast cell. It is these extracts that
are responsible for the increase of such phenomena as increased cell
respiration, cell proliferations, and cell metabolism.
Live Yeast Cell Derivative (LYCD) has been used for several distinct purposes,
pointing to the overall utility of this material in relationship to the
treatment of living organisms. The first widespread use of LYCD began far from
the Cosmetic arena. American Home Products utilized LYCD as the active in the
well-known anti-hemorrhoid product Preparation H®. Legend has it that some
adventurous fashion models brought about the crossover into cosmetics. Having
begun to manifest one of the most visible symptoms of sleep deprivation, the
models began to dab LYCD containing creams on the bags under their eyes. As
would be expected the swelling subsided, the practice spread by word of mouth,
and a core Cosmetic raw material was born.
America, South America, and Europe LCYD is primarily used to stimulate oxygen
consumption, combat irritation, as, what could probably be best termed, a
cosmetic potentiator. The rationale behind increasing oxygen consumption is
that the more efficiently a cell consumes oxygen, the less oxygen is available
to become excited to form destructive reactive oxygen species (ROS).
mechanism by which LYCD reduces irritation has only recently become clear with
the increased focus on the field of Heat Shock Proteins (Hsp). When cells are
subject to stress, be it physical or emotional, they produce a class of
proteins that either duplicate functions disabled by the stress, or protect the
cell against additional stress. It is speculated that one or more of the
components of LYCD is actually a Hsp. Given the similarity between yeast and
human cells it is probable that when applied the Hsp(s) help to reduce, or
reverse the actual stress presented to the human cell.
Given that LYCD is a global metabolic stimulant, as opposed to
working on a single pathway, it is capable of potentiating the activity of
other active ingredients. While the specific application is covered the
possible applications are broad, especially in conjunction with actives such
as Retinol, and its associated compounds, where irritation is an unwanted
side-effect. Hans A. Schaeffer, widely recognized for his role in popularizing
the use of LYCD in the cosmetic field, in conjunction with Henry Calam, were
issued a patent (US 5,057,497) for the use of LYCD in maintaining healthy gingival
tissue. In Asia, LYCD is primarily used to increase the translucency of skin.
Translucency is especially important for whitening applications. The idea being
that if skin is more translucent it is much easier to appreciate the evenness
of skin-tone achieved with whitening products. Many major Cosmetic Companies
such as Pacific, Shiseido, Max Factor, Avon, Coreana, and Kanebo all utilize
yeast extracts as a core raw material in their skin care products.
species of yeast exist with the most well-known yeast being Saccharomyces
cerevisiae. Saccharomyces cerevisiae better known as bakers or
brewer’s yeast, although cherished for its fermentation abilities, was once
considered to be an inutile organism by the scientific world. Within the past 30-40
years the wonders of yeast have finally been recognized. Because yeast cells
are very similar to human cells in composition and structure, they make for a
perfect palate to research scientists. Like a human cell, a yeast cell is a
true eukaryote. It has a nucleus that contains the nucleoli and chromosomes,
which are separated from the cytoplasm by a nuclear membrane. Yeast cells have
17 chromosomes, while human cells have 23 chromosomes, but their structures are
very similar. Yeast also has two genders and reproduces with cells that are
similar to humans’ means of fertilization. In 1996, the yeast cell became the
first living organism to have a completely mapped genome.
been used since prehistoric times in the making of breads and wines. The
Egyptians are often credited with discovering the beneficial properties of
yeast over 6,000 years ago for the making of leavened breads, wine and beer.
It is believed that some yeast cells found their way into an open vat of
crushed grapes, which then turned the juice into wine. Unaware of how this
phenomenon worked, they continued to amass the yeast sediment that collected at
the bottom of each batch and then added it to the next vat of crushed grapes,
continuing the wine production process. However, it wasn’t until the 1850s that
Louis Pasteur discovered that fermentation is simply the metabolic by-product
Then in 1896, German chemist Eduard Büchner discovered that the
fermentation enzymes found in yeast cells would remain active even after extraction
from the cells as long as they were not boiled. This discovery soon paved way
for the delineation of the biochemical process of fermentation as well as the
rising of bread.
Through decades of thorough research and experimentation
following Dr. Sperti’s original work, LYCD has been proven to increase the rate
at which cells consume oxygen. The increase in oxygen consumption is actually
merely a symptom of a global increase in metabolism. Traditionally the activity
of LYCD was measured using the Warburg test. The test involved the use of
defatted rat abdominal skin where the oxygen consumption was measured using a
manometer. Where one unit of respiratory activity is defined as the quantity of
LYCD required to increase the oxygen uptake of 1 mg of tissue by 1% at the end
of 1 hour. The Warburg method eventually was shown to be a good indicative
measure but difficult to correlated from researcher to researcher. The modern
incarnation of this assay involved the use of mouse liver cells where the oxygen
consumption is measured by an oxygen electrode. This method is highly
reproducible, but does relay on animal tissue. LYCD during the course of its
existence has become a well-understood product, where it is generally believed
that the active ingredients are a low molecular weight glycopeptides. UV
absorbance at 256 nm has been closely correlated with respiratory units and is
generally accepted as a non-animal alternative.
of FSS Dermal Respiratory Factor
• Global Metabolic Stimulant
• Efficacious Soothing Benefits
• Promotes Wound Healing
• Stimulates Collagen Production
• Stimulates Elastin Production
• Increases Cellular Respiration
Water & Saccharomyces Lysate Extract
Suggested Use Levels:
Storage: Protected from direct light and humidity at a temperature of 50°-77°F (10°-25°C)
Shelf life: 12 months, properly stored, in sealed container.
This product should be added to a formulation at the recommended usage rate
1) Osterburg, A. and Keller, S.J. (2008) “Live yeast cell derivative induces c-fos expression in THP-1 monocytes”. Journal of Medicinal Chemistry. 2008 May;4(3):264-72.
2) Bnetley, J.P., et al (1990) “Peptides from live yeast cell derivative stimulate wound healing”. Archives of Surgery. 1990 May;125(5):6416. 3) Rieselman, D. (2002) "Secrets of Sperti Ointment revealed: The Whole Story". University of Cincinnati Magazine. University of Cincinnati. http:// magazine.uc.edu/famousalumni/inventors/sperti.html. Retrieved 2002.