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FSS EGF Liposome PF
FSS EGF Liposome PF


 

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Starting at:$185.00


Product Code: FSS60155


FSS EGF Liposome:
2 oz
8 oz
1 kg (2.2 lbs)

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Description
 


FSS EGF Liposome PF

EGF = Epidermal Growth Factor

Naturally Preserved with Leucidal Liquid



Healing and regeneration are two important concerns for providing optimum skin care. Aging is viewed as a process of small scale injury that accumulates over time. Addressing this damage isn’t just a trend, but more of a consumer desire that has spanned the ages. Evidence of this includes the ancient Egyptians use of dairy products on their skin to leave it looking smooth and feeling supple. A more mod­ern day interpretation of this desire is the use of Live Yeast Cell Derivative (LYCD). Fashion models began this ingredient trend in cosmetics during the 1970s, when they started using Preparation H to soothe their tired-looking eyes. Current tech­niques that are being employed to address the desire for healing and regeneration include bio-technologically derived actives such as Epidermal Growth Factor (EGF).



EGF is a strong promoter of epithelial and fibroblast proliferation. It is widely recognized for its ability to enhance wound repair by promoting collagen production. As we age, our dermis and epidermis thin and barrier function becomes com­promised. This results in wrinkle formation and dry skin. Unfortunately, the loss in hydration compounds the problem by making wrinkles more apparent. Research indicates that EGF is capable of thickening tissue layers while enhancing barrier function. This will minimize the appearance of wrinkles and improve hydration. A study commissioned by the Department of Surgery at Emory University in Atlanta, Georgia illustrated the wound reparative properties of EGF on 12 subjects. Researchers reported a significant increase in the rate of wound repair on all 12 subjects when compared to the placebo. After one day subjects had a 25 to 50% rate of improved healing. By day two, researchers reported a 75 to 100% rate of recovery on areas treated with EGF. Other research indicates that EGF is capable of enhancing DNA replica­tion to further promote regeneration thus ensuring wound repair. A study performed on human excised skin tissue has revealed that upon injury, EGF is released in the skin and activates EGFR (epidermal growth factor receptor). Inhibition of EGF in this study was shown to retard reepithelization.



EGF is perhaps one of the best understood signaling pathways in the human body. It plays an important biological role and is responsible for cellular growth, proliferation, differentiation and survival. Using EGF in topical applications may enhance reparative to reduce the appearance of wrinkles and help even skin tone. To meet the current needs of today’s formulator, this has been encapsulated with human recombinant EGF in a liposome. The liposome will enhance de­livery to accelerate EGF’s activity. EGF is a 53 amino acid sequence peptide with a molecular weight of 6,200 Daltons. It is bio-technologically derived using E. coli. When formulating with EGF Liposome, it is advised to maintain a tem­perature below 45˚C and a pH between 4 & 7.


Studies Available for this product upon request:

Cell Proliferation Assay

Irritation Analysis

INCI Nomenclature:

Water & Phospholipids & rh-Oligopeptide-1

Suggested Use Levels:

1.0-10%

Application:

Anti-Aging & Conditioning

Appearance:

Liquid Liposomal Dispersion

pH (Direct):

4.5-6.5

Particle Size:

300 nm Maximum

Storage: Protected from direct light and humidity at a temperature of 50°-77°F (10°-25°C)
Shelf life: 12 months, properly stored, in sealed container.

This product should be added to a formulation at the recommended usage rate.

References:

1) Brown, GL. et. al. Enhancement of wound healing by topical treatments with epidermal growth factor. The New England Journal of Medicine. Volume 321:76- 79. July 13, 1989. [Retrieved: July 7, 2009].

2) Nanney, Lillian. Epidermal and dermal effects of epithelial growth factor during wound repair. Jounal of Investigative Dermatology (1990) 94, 624-629.

[Retrieved: July 7, 2009].

3) Jo, Byoung Kee. Cosmetic composition for skin care containing retinol and epidermal growth factor. Unites States Patent 6,589,540. [Retrieved: July 9, 2009].

4) Mitchell, Claudia. et. al. HB-EGF links hepatocyte priming with cell cycle progression during liver regeneration. J. Biol. Chem, 10.1074. November 4, 2004.

[Retrieved: July 9, 2009].

5) Sorensen, Ole. et. al.Injury-induced innate immune response in human skin mediated by transactivation of the epidermal growth factor receptor. J. Clin.

Invest. 116(7): 1878- 1885 (2006). [Retrieved: July 9, 2009.]

6) Oda, Kanae. et. al. A comprehensive pathway map of epidermal growth factor receptor signaling. Mol Syst Biol. 2005; 1: 2005.0010.

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