FSS EGF Liposome PF
EGF = Epidermal Growth Factor
Naturally Preserved with Leucidal Liquid
Healing and regeneration are two important concerns for
providing optimum skin care. Aging is viewed as a process of small scale injury
that accumulates over time. Addressing this damage isn’t just a trend, but more
of a consumer desire that has spanned the ages. Evidence of this includes the
ancient Egyptians use of dairy products on their skin to leave it looking
smooth and feeling supple. A more modern day interpretation of this desire is
the use of Live Yeast Cell Derivative (LYCD). Fashion models began this
ingredient trend in cosmetics during the 1970s, when they started using
Preparation H to soothe their tired-looking eyes. Current techniques that are
being employed to address the desire for healing and regeneration include
bio-technologically derived actives such as Epidermal Growth Factor (EGF).
EGF is a strong promoter of
epithelial and fibroblast proliferation. It is widely recognized for its
ability to enhance wound repair by promoting collagen production. As we age,
our dermis and epidermis thin and barrier function becomes compromised. This results
in wrinkle formation and dry skin. Unfortunately, the loss in hydration
compounds the problem by making wrinkles more apparent. Research indicates that
EGF is capable of thickening tissue layers while enhancing barrier function.
This will minimize the appearance of wrinkles and improve hydration. A study
commissioned by the Department of Surgery at Emory University in Atlanta,
Georgia illustrated the wound reparative properties of EGF on 12 subjects.
Researchers reported a significant increase in the rate of wound repair on all
12 subjects when compared to the placebo. After one day subjects had a 25 to
50% rate of improved healing. By day two, researchers reported a 75 to 100%
rate of recovery on areas treated with EGF. Other research indicates that EGF
is capable of enhancing DNA replication to further promote regeneration thus
ensuring wound repair. A study performed on human excised skin tissue has
revealed that upon injury, EGF is released in the skin and activates EGFR
(epidermal growth factor receptor). Inhibition of EGF in this study was shown
to retard reepithelization.
EGF is perhaps one of the best
understood signaling pathways in the human body. It plays an important
biological role and is responsible for cellular growth, proliferation,
differentiation and survival. Using EGF in topical applications may enhance
reparative to reduce the appearance of wrinkles and help even skin tone. To
meet the current needs of today’s formulator, this has been encapsulated with human recombinant EGF in a
liposome. The liposome will enhance delivery to accelerate EGF’s activity. EGF
is a 53 amino acid sequence peptide with a molecular weight of 6,200 Daltons.
It is bio-technologically derived using E. coli. When formulating with EGF
Liposome, it is advised to maintain a temperature below 45˚C and a pH
between 4 & 7.
Studies Available for this
product upon request:
Water & Phospholipids & rh-Oligopeptide-1
Suggested Use Levels:
Anti-Aging & Conditioning
Liquid Liposomal Dispersion
300 nm Maximum
Storage: Protected from direct light and humidity at a temperature of 50°-77°F (10°-25°C)
Shelf life: 12 months, properly stored, in sealed container.
This product should be added to a formulation at the recommended usage rate.
1) Brown, GL. et. al. Enhancement of wound healing by topical treatments with epidermal growth factor. The New England Journal of Medicine. Volume 321:76- 79. July 13, 1989. [Retrieved: July 7, 2009].
2) Nanney, Lillian. Epidermal and dermal effects of epithelial growth factor during wound repair. Jounal of Investigative Dermatology (1990) 94, 624-629.
[Retrieved: July 7, 2009].
3) Jo, Byoung Kee. Cosmetic composition for skin care containing retinol and epidermal growth factor. Unites States Patent 6,589,540. [Retrieved: July 9, 2009].
4) Mitchell, Claudia. et. al. HB-EGF links hepatocyte priming with cell cycle progression during liver regeneration. J. Biol. Chem, 10.1074. November 4, 2004.
[Retrieved: July 9, 2009].
5) Sorensen, Ole. et. al.Injury-induced innate immune response in human skin mediated by transactivation of the epidermal growth factor receptor. J. Clin.
Invest. 116(7): 1878- 1885 (2006). [Retrieved: July 9, 2009.]
6) Oda, Kanae. et. al. A comprehensive pathway map of epidermal growth factor receptor signaling. Mol Syst Biol. 2005; 1: 2005.0010.