Hemp Oil Liposome PF
Preserved with Leucidal Liquid
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aging accelerated by inflammation, is the turning point driving the skin care
industry. Cannabinoids and cannabidiol (CBD) are the new darlings of the
anti-inflammatory market and scientific discoveries in that area are driving
the industry forward. FSS Hemp Oil Liposome PF capitalizes on the anti-inflammatory benefits associated
with hemp oil while using modern encapsulation technology to enhance activity
the concept linking underlying inflammatory changes to the causes of most
age-associated diseases. Inflammation is a driving force behind the skin aging
process, leading to a breakdown of the extracellular matrix and consequential
skin wrinkling.1 Inflammation is the body’s response to cellular aggression
or injury. It represents a defense mechanism designed to heal cells from injury
and protect the body. Inflammation also facilitates early tissue healing and
repair, and allows the body to restore itself to a normal form and function.
All skin is subject to inflammation, even at low intensities. It is this
underlying inflammation that ultimately exhausts the body’s defense system,
dismantling key youth-sustaining skin structures, and resulting in collagen and
elastin degradation, as well as a breakdown of the skin’s barrier function.2 Inflammaging can be alleviated and prevented by the use of
topical products formulated with anti-inflammatory actives.
Humans have made
use of the hemp plant — and its nutritional benefits — since the beginning of
written history. It is believed that weaving of hemp fibers began thousands of
years ago and have been used industrially to manufacture rope, canvas, paper,
and clothing. After the discovery of textiles and synthetics, hemp fiber
weaving or manufacturing began to disappear. Today hemp products are making a
comeback particularly with hemp oil.
Hemp oil is
produced by gentle cold press extraction from the specialized varietals of the
hemp plant of the Cannabis genus. The plants used for the extractions are
specifically cultivated to have the insignificant amounts of the psychoactive
substances associated with the genus, most notably the tetrahydrocannabinol
(THC). FSS Hemp Oil Liposome PF is
manufactured using hemp oil rich in CBD. CBD is a common cannabinoid found in
the cannabis plant. While the hemp oil we use contains high CBD, it is not the
same thing as CBD oil, which is a purified hemp oil product. When strains are
high in CBD, they are subsequently very low in THC, typically containing <
0.3% THC. The produced hemp oil does not have psychoactive properties.
FSS Hemp Oil Liposome PF contains
hemp oil extracted from the whole hemp plant. Hemp contains a symphony of over
400 compounds including CBD, secondary phyto-cannabinoids, terpenoids,
terpenes, and flavonoids. These compounds work synergistically to heighten the
positive, therapeutic effects of cannabidiol. The “Entourage Effect” is a term
coined by scientists in 1998 to describe their study findings that taking all
of the natural chemicals found in cannabis are more beneficial than just taking
a single molecule compound.
The “Entourage Effect”
describes the enhancement of efficacy, with related improvement in overall
therapeutic effectiveness, derived from combining phytocannabinoids and other
plant-derived molecules. Hemp has quite an entourage of phyto-cannabinoids,
which are unique chemical compounds. The most prominent is cannabidiol, the
non-psychoactive cannabinoid that has shown to have the largest potential for
wellness benefits in hemp. Cannabidiol is accompanied by other cannabinoids
such as tetrahydrocannabinol, tetrahydrocannabivarin, cannabigerol,
cannabichromene, and cannabinol. A CBD product made with isolated CBD will not
contain these other beneficial factors. Cannabinoids
are considered potent anti-inflammatory agents and exert their effects through
induction of apoptosis, inhibition of cell proliferation, suppression of
cytokine production and induction of T-regulatory cells.3 FSS
Hemp Oil Liposome PF encapsulates hemp oil into liposomes for enhanced delivery and
effective anti-inflammation benefits.
can be used in the delivery of various cosmetic materials, vitamins, and
minerals throughout the body, typically to the skin, for an array of
advantages. The liposomes may attach and fuse to the cellular membranes,
releasing their contents into the target cells. Liposomes are microscopic
vesicles that consist of an aqueous center with a phospholipid membrane.
Phospholipids contain a glycerol bonded to two fatty acids and a phosphate
group with a polar head. The fatty acid portion of this biomolecule is
hydrophobic and is located toward the outside of the lipid bilayer whereas the
phosphate group is hydrophilic and faces the aqueous interior. These
phospholipid walls are identical to those that comprise other human cell
membranes. Liposomes act as vehicles to transport nutrients to the cells
through layers of skin and enhance delivery of active ingredients.
non-encapsulated materials are placed on the skin a range of factors determine
the fate of the material. Stability, solubility, lipophilicity, and size are
all obstacles the active must overcome to penetrate the epidermal barrier.
Liposomes, which resemble the basic structures of cellular membranes, create a
more beneficial interaction with skin cells. The structure and amphiphilic
nature allows the liposomes to penetrate the epidermal barrier and travel
deeper than free materials to deliver the anticipated results.
Liposomes are readily
compatible with epidermal surface lipids, the skin’s primary moisture barrier,
as these epidermal lipids exist as lamellar bilayers. Lamellar bilayers require
less moisture to maintain their structure. When a liposome fuses with the
epidermal lipids, the epidermal lipid structure becomes overloaded with water
and out of equilibrium. To restore equilibrium, the water and phospholipid, as
well as the active loaded, are rapidly churned through the top cell layers of
the stratum corneum. Enhanced delivery of the active occurs as it is rapidly
carried down through the stratum corneum. Liposomes’ proven delivery system
yields a multitude of benefits; enhancing the penetration of actives yielding
increased efficacy, offering time release mechanisms, protecting and delivering
otherwise unstable ingredients, and the ability to target specific cells.
FSS Hemp Oil Liposome PF can
be used to reduce inflammation and capitalize on the benefits of hemp oil in a
variety of hair and skin care formulations. The inhibition of Interleukin-6
activity by FSS Hemp Oil Liposome PF may help to alleviate the chronic
inflammatory process, which is linked to the process of skin aging and the
formation of fine lines and wrinkles.
FSS Hemp Oil Liposome PF exhibited
anti-inflammatory effects in an in-vitro Interleukin-6 ELISA model.
Cytokines are the signaling proteins synthesized and secreted by immune cells
upon stimulation. They are the modulating factors that balance initiation and
resolution of inflammation. During chronic inflammation, Interleukin-6 (IL-6)
suppression can decrease tissue injury. IL-6 is a pro-inflammatory cytokine
known to play an active role in inflammation, immunology, and aging. IL-6
signals through the nuclear factor-kappa B (NF-κB) pathway that results in the
transcription of inflammatory mediators, including matrix
metalloproteinase-1(MMP-1). MMP’s are responsible for breaking down the
extracellular matrix and collagen in the skin leading to wrinkles, fine lines,
and loss of skin elasticity. Reducing the level of IL-6 and other inflammatory
mediators is believed to slow down degradation of the skin matrix and stimulate
IL-6 ELISIA assay was conducted to assess the changes in IL-6 levels in
cultured human dermal fibroblasts treated, in-vitro, with FSS Hemp Oil
Liposome PF. FSS Hemp Oil Liposome PF exhibited
anti-inflammatory effects on LPS-treated fibroblasts. This decrease in IL-6
production indicates a reduced inflammatory environment.
Hemp Oil Liposome PF decreased IL-6 concentration by 83.77% at a 0.5% use level and
by 99.22% at a 1.0% use level. Non-encapsulated CBD oil was tested for added
perspective. Results of this IL-6 ELISA assay demonstrate that 1.0% FSS Hemp
Oil Liposome PF reduces IL-6 concentration 45.51% more than 1.0% CBD oil.
This data suggests that FSS Hemp Oil Liposome PF enhances soothing and
anti-aging properties at normal use concentrations.
during the cooling phase of the formulation. Avoid long exposure to heat.
Temperature Stability: Stable up to 50°Celsius
pH Stability: 3 to 7 pH
Suggested Usage Rates: 1-10%
Solubility: Water Dispersible
refer to our Safety Statement and Regulatory Statement regarding FSS Hemp Oil Liposome PF
Water & Phospholipids & Cannabis Sativa
Beige to Yellow,
Liquid Liposomal Dispersion
Protected from direct light and humidity at a temperature of
Shelf life: 12 months, properly stored, in sealed container.
This product should be added to a formulation at the recommended usage rate.
Makoto, Inflammaging (inflammation + aging): A driving force for human aging
based on an evolutionarily antagonistic pleiotropy theory?, Biosci Trends 2 6
2. C Franceschi,
et al., Inflamm-aging. An evolutionary perspective on immunosenescence, Ann NY
Acad Sci 908 244–54
Prakash et al. “Cannabinoids as novel anti-inflammatory drugs” Future medicinal
chemistry vol. 1,7 (2009): 1333-49.
P. G., & Rosenfeld, M. J. (2013). The endocannabinoid system, cannabinoids,
and pain. Rambam Maimonides medical journal, 4(4), e0022.
R., Yekhtin, Z. and Hanuš, L.O. (2015) Overcoming the Bell‐Shaped Dose‐Response of
Cannabidiol by Using Cannabis Extract Enriched in Cannabidiol. Pharmacology
& Pharmacy, 6, 75‐85.