Organic Unloaded Liposome RS

Organic Unloaded Liposome RS is an unloaded delivery system

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 Organic Unloaded Liposome RS


Using organic phospholipids, and the latest encapsulation technologies, Arbor Organic Technologies has developed several novel delivery systems. Organic Unloaded Liposome RS was designed as a USDA organic certified solution for targeted delivery, enhanced efficacy, and a tailored consumer experience.



Liposomes can be used in the delivery of various cosmetic materials, vitamins, and minerals throughout the body, typically to the skin, for an array of advantages such as antioxidant benefits, conditioning, and antimicrobial purposes. The liposomes may attach and fuse to the cellular membranes, releasing their contents into the target cells. Liposomes are microscopic vesicles that consist of an aqueous center with a phospholipid membrane; phospholipids contain a glycerol bonded to 2 fatty acids and a phosphate group with a polar head. The fatty acid portion of this biomolecule is hydrophobic and is located toward the outside of the lipid bilayer whereas the phosphate group is hydrophilic and faces the aqueous interior. These phospholipid walls are identical to those that comprise other human cell membranes.

When non-encapsulated materials are placed on the skin a range of factors determine the fate of the material. Stability, solubility, lipophilicity, and size are all obstacles the active must overcome to penetrate the epidermal barrier. Liposomes, which resemble the basic structures of cellular membranes, create a more beneficial interaction with skin cells. The structure and amphiphilic nature allows the liposomes to penetrate the epidermal barrier and travel deeper than free materials to deliver the anticipated results.

Liposomes can differ in size with a range in diameter between 150 - 3500nm, and they can be found in unilamellar and multilamellar forms.4 While multilamellar structures are great for specific tasks, they are not stable as raw materials or in formulations. Unilamellar vesicles are small, exceptionally stable molecules offering high stability for the incorporation into personal care products.




Liposomes’ proven delivery system yields a multitude of benefits; enhancing the penetration of actives yielding increased efficacy, offering time release mechanisms, protecting and delivering otherwise unstable ingredients, and opening the door to the ability to target specific cells. Organic Unloaded Liposome RS is an unloaded delivery system that allows for the customized encapsulation of actives in a USDA certified organic vehicle. Unloaded Liposomes offer the opportunity to encapsulate active ingredients for enhanced delivery mechanism. Therefore, depending on use level and solubility profile, this liposome could be loaded by the customer with their desired active ingredient. 

Encapsulation Technology

Unloaded Delivery System

Enhances Delivery of Active

Rice Solution (RS) is used as a glycerin alternative due to its moisturizing benefits and viscosity 

Please refer to our Organic Rice Solution


Tips for loading liposome

This liposome comes unloaded with the ability to load your own desired active ingredient. We recommend using shear force with a Silverson homogenizer to load liposomes. This liposome should be able to handle up to roughly 20,000 PSI safely. However, it’s really impossible to say for sure without analyzing the specific formulation. Although anything under 20k PSI will be fine, customers should always verify that for their particular formula and filling process.

You can add the active directly to the liposome mix. The amount of the active able to be loaded really depends on the nature of the specific active you are using. For example, for a water soluble active, the highest realistic percentage able to load is likely 10% and then 1% for an oil soluble active.

It is also important to monitor the temperature and not overheat the liposome, so as not to disturb the phospholipid bilayer. Liposomes are heat stable up to 50°C.

INCI Nomenclature: Oryza Sativa (Rice) Extract & Water & Phospholipids
Solubility: Water Dispersible 
Suggested Use Levels: 1.0 - 10.0% 
Suggested Applications: Unloaded Delivery System, Enhances Active Delivery 
**Note: Product may change appearance if exposed to cold temperatures during shipment or storage. If this happens, please gently warm to 45-50°C and mix until normal appearance is restored. Lot to lot variation may exist beyond our control due to seasonal weather and resulting crop variations in our supply of the natural plant materials.
Storage: Protected from direct light and humidity at a temperature of 50°-77°F (10°-25°C)
Shelf life: 12 months from the date of manufacture, properly stored, in sealed container.
This product should be added to a formulation at the recommended usage rate.

All products sold are cosmetic grade; External Use Only; Cosmetic & Personal Care Formulations Only.

Our products are for cosmetic and personal care formulations only; External Use Only. We recommend working with a chemist or a formulator if you’re not advanced in formulating.

Statements contained herein have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat and cure, or prevent disease.


  1. Unloaded
    I used the Unloaded liposome before and love it. I will try this since it is organic to see the main difference. When I first purchased the other one, I thought I could load it until I read back. Believe it or not, the benefits are in those phosoplipids!

    Formulator Sample Shop's Response:

    Thank you so much for your comment & review! We appreciate you and your continued support! Yes, you're correct, Phosoplipids have so many wonderful benefits and properties to them.

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