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Product Code: FSS20452PF

1 oz
2 oz
8 oz
1 kg (2.2 lbs)
3 kgs (6.6 lbs)
5 kgs (11 lbs)


FSS Collagen PrePeptide PF
Paraben Free - Preservative Free
(Preserved with Leucidal Liquid)

Collagen, the fourth most abundant protein found in the body, is the principal structural protein found in the body’s molecular scaffolding. The scaffolding is a complex matrix of proteins and proteoglycans that support the internal organs as well as the skin.

Collagen itself, like all proteins, is a heteropolymer composed of more than 1400 amino acid residues linked via peptide bonds. What distinguishes col­lagen is the degree to which those amino acid residues are conserved. Every third residues is a glycine molecule. Most typically the glycine is then followed by proline and hydroxyproline. In fact it is the presence of the proline that con­tributes to collagen’s dense structure. Hydroxyproline, formed by the oxidation of proline in the presence of Vitamin C, stabilizes the collagen helix.

Many researchers over the years have determined that breaking down collagen with either alkaline, or enzymatic hydrolysis produces a product that can increase the collagen production of cultured cells three-fold.

Alkaline and to a lesser extent enzymatic hydrolysis produce random peptide fragments which cannot be relied upon to produce consistent results in cell culture models. Further biochemical research has revealed that the sequence Glycine-Proline-Hydroxyproline (G-P-Hyp) is the active present in collagen hydrolysates.

Having determined the active principal, two hurdles remained: delivery and economics. Traditional collagen hydrolysates have a molecular weight greater than 1000 Daltons (D) and as such are not capable of readily pen­etrating the skin. While it is possible to hydrolyze the protein reducing the molecular weight to less than 300 D, which would allow penetration, it is not possible to do so while producing a product of adequate purity. Advances in peptide synthesis centered on a new base labile amino-pro­tective group overcome the question of purity and have made feasible the economic commercial production of pure peptides.

FSS Collagen Prepeptide PF is pure (>99.7%) G-P-Hyp tripeptide produced synthetically, without the use of animal de­rived products or genetically modified organisms. With a molecular weight of 285 D it shows excellent bioavailability. In-vitro experiments have shown that this material will dramatically increase synthesis of Collagen.

INCI Nomenclature:


Suggested Use Levels:



Clear to Hazy Liquid

Solubility In Water:


Storage: Protected from direct light and humidity at a temperature of 50°-77°F (10°-25°C)
Shelf life: 12 months, properly stored, in sealed container.

This product should be added to a formulation at the recommended usage rate.


1) Oesser et al., 2003 (Cell & Tissue Research , 311, 393-399) - showed in tissue culture HC stimulate collagen synthesis and secretion of chondrocytes

with degraded collagen.

2. Blow, Nathan (2009). "Cell culture: building a better matrix". Nature Methods 6 (8): 619–622.

3. Fraser, R., D.; MacRae, T. P. and Miller, A. (1987). "Molecular packing in type I collagen fibrils". Journal of Molecular Biology 193 (1): 115–125.

4. Orgel, J. P.; et al.(2006). "Microfibrillar structure of type I collagen in situ". PNAS 103 (24): 9001–9005.

Average Rating: Average Rating: 5 of 5 5 of 5 Total Reviews: 1 Write a review »

  13 of 13 people found the following review helpful:
5 of 5 Wonderful Results! December 12, 2012
Reviewer: Cindy from Dallas, TX  
I was a little hesitate to purchase this product, but after speaking with a friend of mine she said to use it at a low level.
I used it at 0.2% and I have to say this has made the difference in my product. My end product is selling like crazy and I just want to say Thank you for having this product.
From your loyal customer,

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