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FSS HYALUROSOME
FSS HYALUROSOME


 

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Product Code: FSS26001


FSS HYALUROSOME:
2 oz
8 oz
1 kg (2.2 lbs)
2 kgs (4.4 lbs)
4 kgs (8.8 lbs)

Qty:  
Description
 



BACKGROUND

Some people swear that timing is everything. Although this may seem a bit dramatic, we do know that timing can certainly play a pivotal role in the success or failure of a product launch. Interestingly, consumers are now focusing more on timing, but under different circumstances. FSS Hyalurosome was designed to deliver all of the benefits of Hyaluronic acid in a time-release package for prolonged and effective delivery.


As a result, the rise in products that claim to deliver time-release technology has increased dramatically. Our response has been to develop FSS Hyalurosome, a unique alternative to more traditional delivery systems. In fact, FSS Hyalurosome represents a significant advance in the development of hybrid vesicular delivery technology. Traditionally liposomes enhance the penetration of actives into the skin. However, because liposomes disassociate on the skin’s surface, they do little to protect water labile or water-activated materials. FSS Hyalurosome is based on a solid core formed from a silicone copolymer.


SCIENCE

This copolymer is porous in nature allowing it to be loaded with a variety of actives. In this case, the active is high molecular weight Hyaluronic Acid as a dehydrate. When exposed to a hydrophilic environment the hyaluronic acid is able to rapidly absorb moisture, causing it to swell. In order to prevent this swelling effect from occurring in the formula instead, the silicone core is coated with a unilamellar phospholipid bilayer; effectively shielding the payload until it reaches the stratum corneum.


This bilayer exhibits a hydrophilic exterior making it suitable for modern, oil in water or silicone in water emulsions. Yet application to the skin causes the phospholipid bilayer to shear, thus activating the hyalurosomes to allow for the continued release of hyaluronic acid. Once hydrated, the hyaluronic acid will effectively moisturize and plump the skin. The time release feature of this technology is a result of two factors associated with the silicone core.


The first factor is a variation in the size of the pores within the copolymer. The second is the tortuosity of the pores, or more simply how convoluted the pores are within the core matrix. To better observe the time release properties of our FSS Hyalurosome a moisturization study was performed comparing the hydrating benefits of our product to that of hyaluronic acid over the course of a ten hour period.


BENEFITS


FSS Hyalurosome is beneficial for formulations that require time released moisturization in the most technologically advanced method on the market. Capitalizing on the popularity of Alpha-HydroxyAcids, FSS Hyalurosome is a must have for top of the line cosmetics that require a scientific backbone.


EFFICACY DATA

As seen in the below figure, FSS Hyalurosome is able to deliver time sensitive moisturization for a period that far exceeds that of traditional Hyaluronic acid. This time delayed release has led to FSS Hyalurosome to being one of the most potent and effect moisturizing agents on the market.


Presentation, Technical Data Sheet and Studies available upon request.


To better observe the time release properties of our FSS Hyalurosome a moisturization study was performed comparing the hydrating benefits of our product to that of hyaluronic acid over the course of a ten hour period. 10 (m/f) subjects between the ages of 22 and 43 applied three different lotions to 2cm2 areas of their volar fore­arms. The lotions consisted of an o/w emulsion base supplemented with 0.05% FSS Hyalurosome and 0.05% Hyaluronic Acid which was used as the positive control. The blank o/w emulsion base was also used as a negative control. As anticipated both Hyaluronic Acid and FSS Hyalurosome are capable of comparably hydrating the skin. However the key difference is how long the hydrating properties last. FSS Hyalurosome was capable of continu­ously hydrating the skin over the course of the 10 hour period. However a decrease in hydration was observed on test sites treated with the hyaluronic acid lotion after 6 hours as is indicated in the Figure below. Clearly these results indicate that FSS Hyalurosome is capable of providing sustained activity.



Formulation Guidelines:
Soluble in oil. It can be added in the oil phase or post emulsification at around 50 -55 degrees Celsius


INCI Nomenclature:

Water & Polydimethylsiloxane/Polymethylsilsesquioxane Copolymer & Phospholipids & Hyaluronic Acid

Appearance:

Semi-Viscous White Liquid

Suggested Usage Levels:

0.1-1.0%

Suggested Application:

Time Release Hydration & Moisturization

pH: (1% Solution)

5.0 – 7.0

Storage: Protected from direct light and humidity at a temperature of 50°-77°F (10°-25°C)
Shelf life: 12 months, properly stored, in sealed container.

This product should be added to a formulation at the recommended usage rate.




References

1) Sidwell, R. et al. 2004. Clinical and Experimental Dermatology. Localized granulomatous reaction to a semi-permanent hyaluronic acid and acrylic hydrogel cosmetic filler. 29(6): 630-632. 2) Barnes, L. et al. 2013. Journal of Investigative Dermatology. Inhibition of Putative Hyalurosome Platform in Keratinocytes as a Mechanism for Corticosteroid-Induced Epidermal Atrophy. 133: 1017-1026. 3) Manca, M. et al. 2015. Biomaterials. Development of curcumin loaded sodium



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