FSS Immobilized Papain PF
Preserved with Leucidal Liquid
What’s en vogue now for cosmetics aren’t the most extravagant ingredients that consumers can barely afford, nor is it something that’s at the peak of cutting edge science that customers can barely understand. Ultimately the most sought after cosmetics as of late are simple, natural and functional ingredients that are not only perceived to be good for us, but also leave our skin feeling rejuvenated and revitalized.
Texture is important. Our skin won’t look beautifully flawless and healthy unless it’s smooth and moisturized. Exfoliation is key. Some of the best exfoliants on the market rely on the use of proteases derived from milk or fruit which are capable of gently disrupting cellular adhesion molecules to remove the outer most layer of dead cells along the skin’s surface. Proteases isolated from papaya are perfect for this application since they are both highly effective and provide exceptional marketing appeal by allowing formulators to capitalize on the super-fruit trend.
In addition to being loved for their flavor, papaya is also a good source of phyto-nutrients that may improve our health. Papain is the respective enzyme in papaya that provides exfoliating properties. This protease has also been used to treat inflammation. What is interesting about our FSS Immobilized Papain PF is that it contains hexamethylene diisocyanate (HDI), a copolymer that functions as a chaperone for the enzyme.
Enzymes are large structures that consist of several different protein sub-units that are linked together and held in place by chaperone proteins. The active site of the enzyme is actually a small segment of the entire protein. The enzyme only works when the active site is capable of coming into contact with the polypeptide sequence for which there is an affinity. When proteins become denatured, they unfold and the active site is no longer capable of binding to the polypeptide sequence. The HDI copolymer in essence functions as a structural backbone to stabilize the Papain so it retains activity longer than naturally stabilized enzymes. Another interesting aspect about using the HDI copolymer is that it prevents self-catabolism, which would normally de-activate the enzyme. By immobilizing the protease with the HDI copolymer, we sterically hinder them to prevent the active site from binding to other portions of the protein. In other words the HDI copolymer will keep the protease from digesting itself, which is a common problem with liquid proteases. The unique symmetrical structure of the copolymer actually creates strong intermolecular forces through hydrogen bonding that result in elastomers with a high tensile strength, which are also pliable for a soft feel on the skin. The polymer’s film forming properties can also help to improve texture.
FSS Immobilized Papain PF will help increase cell renewal. This is important for treating problem skin as excess dead cells trap sebum and dirt on the skin and often clog pores. Proper exfoliation will also help minimize the appearance of fine lines and optimizes translucency to combat dulling effects that occur overtime. Ultimately the protease will leave the skin feeling soft and smooth while creating a rejuvenated aesthetic. When formulating with FSS Immobilized Papain PF, it is recommended to maintain a pH range between 3.5 and 8.5 while keeping a temperature below 65˚C.
This product contains Water,HDI Copolymer, Papain and Leuconostoc/Radish Root Ferment Filtrate (Leucidal Liquid)
INCI Nomenclature: Water & HDI Copolymer & Papain
Appearance: Pale Yellow to Amber Liquid
Suggested Use Levels: 1.0-5.0%
Suggested Applications: Exfoliation
pH: 5.0-7.0
Storage: Protected from direct light and humidity at a temperature of 50°-77°F (10°-25°C)
Shelf life: 12 months from the date of manufacture.
This product should be added to a formulation at the recommended usage rate.
All products sold are cosmetic grade; External Use Only; Cosmetic & Personal Care Formulations Only.
Our products are for cosmetic and personal care formulations only; External Use Only. We recommend working with a chemist or a formulator if you’re not advanced in formulating.
Statements contained herein have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat and cure, or prevent disease.
