FSS EXOETERNOL

FSS EXOETERNOL

Modern life keeps the body in constant overdrive, and as we turn to biohacking and mindfulness to find balance, our skin reflects the strain through visible signs of stress, reduced elasticity, and diminished firmness. In this new era of accelerated change, the skin needs more than renewal — it needs equilibrium. FSS ExoEternol delivers that balance as a biotech-powered retinol alternative rooted at the intersection of modern science and Traditional Chinese Medicine, centered on perilla leaf to help restore the flow of Qi. Through targeted fermentation and exosome-inspired delivery, perilla’s potent bioactives are awakened and stabilized, working in sync to boost collagen synthesis, calm inflammation, and strengthen the skin’s structure, helping to deliver visible renewal without the irritation of retinol.

In the skin, retinol (vitamin A) is converted by enzymes into retinoic acid, the active form that binds nuclear receptors (RARs and RXRs) to regulate gene expression.¹ This process promotes keratinocyte differentiation, supports collagen production, and enhances skin renewal, improving texture, resilience, and appearance. While retinol delivers visible renewal, its use is limited by irritation, regulatory restrictions, and safety concerns during pregnancy. 

FSS ExoEternol rewrites the rules of renewal. Developed through a controlled fermentation of Perilla frutescens, it awakens the plant’s powerful bioactives, including protocatechuic acid, rosmarinic acid, and lactic acid, supported by the biological networks that drive their protective and restorative functions within perilla. Rather than isolating individual actives, the manufacturer preserves the complete metabolic ecosystem responsible for perilla’s natural balance and resilience. Through BioAuthentic Exosomal Technology, FSS ExoEternol captures this biochemical network and the interconnected pathways that sustain its adaptive properties. These pathways are encapsulated within protein-stabilized BioAuthentic Exosomes, maintaining the integrity of perilla’s living synergy to deliver visible renewal without irritation or imbalance. 

Plant-derived actives in perilla, including protocatechuic acid,² have been shown in vitro to increase type I collagen levels and inhibit MMP-1 activity, supporting extracellular matrix integrity.³ Perilla also naturally produces rosmarinic acid, a potent antioxidant that scavenges reactive oxygen species and modulates pro-inflammatory mediators, helping protect skin from oxidative and inflammatory stress.⁴,⁵ Perilla frutescens has been found to contain lactic acid, an alpha hydroxy acid known to promote mild exfoliation by disrupting the bonds between corneocytes, encouraging cell turnover and smoother skin texture.⁶ Together, these bioactives form the foundation of FSS ExoEternol’s skin-renewing benefits, each contributing distinct yet complementary functions within the perilla matrix.

Benefits:

• Exfoliating

• Smoothing

• Renewing

References:

1. Lidén, M, et al. “Understanding Retinol Metabolism: Structure and Function of Retinol Dehydrogenases.” Journal of Biological Chemistry. 281.19 (2006):13001-13004.

2. Hou, T., et al. “Perilla frutescens: A Rich Source of Pharmacological Active Compounds.” Molecules. 27.11 (2022): 3578.

3. Shin PhD, S. et al. “Anti-skin aging properties of protocatechuic acid in vitro and in vivo.” Journal of Cosmetic Dermatology. 4 (2020): 977-984.

4. Deguchi, Y., et al. “Rosmarinic acid in Perilla frutescens and perilla herb analyzed by HPLC.” Journal of Natural Medicines.

5. Phromnoi, K., et al. “Polyphenols and Rosmarinic acid Contents, Antioxidant and Anti-Inflammatory Activities of Different Solvent Fractions from Nga-Mon (Perilla frutescens) Leaf.”

Journal of Pharmacy and Nutrition Sciences. 9 (2019): 239-246.

6. Lee, J., Shin, Y. “Antioxidant compounds and activities of Perilla frutescens var. crispa and its processed products.” Food Sci Biotechnol. 33.5 (2023): 1123-1133.

FSS60200

FSS ExoEternol