FSS DermaPeptide Toning PF
Preserved with Leucidal Liquid
Communication is key! How often have we heard this phrase uttered in
reference to our personal or work relationships? Yet one would rarely think to
apply such a phrase to other situations. However, effective communication
amongst the various cells of our body is vital for our survival, and also
dramatically affects our appearance.
The epidermis is the outer layer of our skin; underneath the 5 layers of
the epidermis is the dermis, which provides oxygen and nutrients necessary for
maintaining the epidermis. Anatomically, the site at which both the dermis and
the epidermis meet is referred to as the dermal epidermal junction (DEJ), and
it consists of an area approximately 100 nm thick. DEJ integrity is vital for
the communication that occurs between the dermis and the epidermis, playing a
role in numerous processes including cellular differentiation, migration,
proliferation and repair. The DEJ is also involved in immune system responses
such as the inflammatory response mechanism, which is triggered via chemical
signals relayed across the dermal epidermal junction. FSS DermaPeptide
Toning PF is intended to improve the integrity of the DEJ by increasing the
synthesis of its components; thus improving the overall appearance of the
complexion by increasing tone and elasticity therefore decreasing the
appearance of fine lines and wrinkles.
The dermal epidermal junction is predominantly constructed out of
collagen types IV and VII as well as glycoproteins such as integrin α2β1,
laminins and other proteins. Many hypothesize that the condition of the DEJ directly affects the
appearance of the epidermis, theorizing its condition is responsible for
wrinkle formation, elasticity and tone. Therefore, if one were to create a
cosmetic to target the DEJ, it would have to effectively improve the various
components that make up the DEJ2.
FSS DermaPeptide Toning PF is intended to improve the DEJ by
increasing the production of collagen IV and VII as well as integrin α2β1. We
have isolated a specific peptide sequence from yeast that may actually increase
the production of collagens IV and VII while improving the concentration of
The efficacy of FSS
DermaPeptide Toning PF was verified by several in vivo and in
vitro studies. A 15 subject panel of women between the ages of 40 and 55
was constructed to determine the effects of FSS DermaPeptide Toning PF on
epidermal characteristics such as elasticity, tone and fatigue. The results
indicated that FSS DermaPeptide Toning PF may actually improve
elasticity and tone while minimizing epidermal fatigue.
A second in vivo study
involved the use of silicone molds to obtain wrinkle impressions around the
outer eye area. Following a 28 day study where both 5% FSS DermaPeptide
Toning PF and placebo were applied to the test sites twice daily, FSS DermaPeptide
Toning PF was observed to reduce the appearance of wrinkles by minimizing
both wrinkle depth and volume to create a smoothing effect. These results
indicate that FSS DermaPeptide Toning PF may be added to anti-aging
products designated to reduce wrinkle appearance and formation.
An in vitro analysis involving fibroblast migration revealed that
FSS DermaPeptide Toning PF increased fibroblast migration to wound sites
after 24 and 48 hours. The study involved the use of fibroblasts cultured in
fibroblast-cultured medium and grown on glass slides. Cultures were wounded and
incubated with either 0.5% FSS DermaPeptide Toning PF, TGF-β1 or the
control. Fibroblast migration was then observed with a compound light
FSS DermaPeptide Toning
also effectively used to increase the synthesis of collagen IV, collagen VII
and integrin α2β1. Fibroblasts were incubated with either 2% FSS DermaPeptide
Toning PF, TGF-B1, or the control for 72 hours.
transcriptase and PCR were used to identify the coding region for each protein.
The concentration of the coding sites is expressed with the intensity of the
bands produced via PCR. FSS DermaPeptide Toning PF was observed to
increase the concentration of the coding sites of collagen IV, collagen VII and
integrin α2β1. Therefore, it may be used to increase the synthesis rate of
collagen IV, collagen VII and integrin α2β
FSS DermaPeptide Toning
be incorporated into lotions, creams and gels that are intended to act as
anti-aging products as well as other products that are designed to reduce the
appearance of physical damage. The various in vitro and in vivo studies
performed on FSS DermaPeptide Toning PF reveal that it may be used to
target the DEJ and improve the overall appearance, tone and elasticity of the
epidermis. As a water soluble, fermented yeast extract, this product can be
incorporated in virtually any aqueous system.
Benefits of FSS DermaPeptide
• Tone & Elasticity
• Collagen Synthesis
• Wrinkle Reduction
Water & Yeast
Colorless to Light Amber
from direct light and humidity at a temperature of 50°-77°F (10°-25°C)
Shelf life: 12 months, properly stored, in sealed container.
should be added to a formulation at the recommended usage rate.