FSS DermaPeptide Toning PF

Preserved with Leucidal Liquid

Communication is key! How often have we heard this phrase uttered in reference to our personal or work relationships? Yet one would rarely think to apply such a phrase to other situations. However, effective communication amongst the various cells of our body is vital for our survival, and also dramatically affects our appearance.

The epidermis is the outer layer of our skin; underneath the 5 layers of the epidermis is the dermis, which provides oxygen and nutrients necessary for maintaining the epidermis. Anatomically, the site at which both the dermis and the epidermis meet is referred to as the dermal epidermal junction (DEJ), and it consists of an area approximately 100 nm thick. DEJ integrity is vital for the communication that occurs between the dermis and the epidermis, playing a role in numerous processes including cellular differentiation, migration, proliferation and repair. The DEJ is also involved in immune system responses such as the inflammatory response mechanism, which is triggered via chemical signals relayed across the dermal epidermal junction. FSS DermaPeptide Toning PF is intended to improve the integrity of the DEJ by increasing the synthesis of its components; thus improving the overall appearance of the complexion by increasing tone and elasticity therefore decreasing the appearance of fine lines and wrinkles.

The dermal epidermal junction is predominantly constructed out of collagen types IV and VII as well as glycoproteins such as integrin α2β1, laminins and other proteins. Many hypothesize that the condition of the DEJ directly affects the appearance of the epidermis, theorizing its condition is responsible for wrinkle formation, elasticity and tone. Therefore, if one were to create a cosmetic to target the DEJ, it would have to effectively improve the various components that make up the DEJ2.

FSS DermaPeptide Toning PF is intended to improve the DEJ by increasing the production of collagen IV and VII as well as integrin α2β1. We have isolated a specific peptide sequence from yeast that may actually increase the production of collagens IV and VII while improving the concentration of various glycoproteins.

The efficacy of FSS DermaPeptide Toning PF was verified by several in vivo and in vitro studies. A 15 subject panel of women between the ages of 40 and 55 was constructed to determine the effects of FSS DermaPeptide Toning PF on epidermal characteristics such as elasticity, tone and fatigue. The results indicated that FSS DermaPeptide Toning PF may actually improve elasticity and tone while minimizing epidermal fatigue.

A second in vivo study involved the use of silicone molds to obtain wrinkle impressions around the outer eye area. Following a 28 day study where both 5% FSS DermaPeptide Toning PF and placebo were applied to the test sites twice daily, FSS DermaPeptide Toning PF was observed to reduce the appearance of wrinkles by minimizing both wrinkle depth and volume to create a smoothing effect. These results indicate that FSS DermaPeptide Toning PF may be added to anti-aging products designated to reduce wrinkle appearance and formation.

An in vitro analysis involving fibroblast migration revealed that FSS DermaPeptide Toning PF increased fibroblast migration to wound sites after 24 and 48 hours. The study involved the use of fibroblasts cultured in fibroblast-cultured medium and grown on glass slides. Cultures were wounded and incubated with either 0.5% FSS DermaPeptide Toning PF, TGF-β1 or the control. Fibroblast migration was then observed with a compound light microscope.

FSS DermaPeptide Toning PF was also effectively used to increase the synthesis of collagen IV, collagen VII and integrin α2β1. Fibroblasts were incubated with either 2% FSS DermaPeptide Toning PF, TGF-B1, or the control for 72 hours.

Reverse mRNA transcriptase and PCR were used to identify the coding region for each protein. The concentration of the coding sites is expressed with the intensity of the bands produced via PCR. FSS DermaPeptide Toning PF was observed to increase the concentration of the coding sites of collagen IV, collagen VII and integrin α2β1. Therefore, it may be used to increase the synthesis rate of collagen IV, collagen VII and integrin α2β

FSS DermaPeptide Toning PF may be incorporated into lotions, creams and gels that are intended to act as anti-aging products as well as other products that are designed to reduce the appearance of physical damage. The various in vitro and in vivo studies performed on FSS DermaPeptide Toning PF reveal that it may be used to target the DEJ and improve the overall appearance, tone and elasticity of the epidermis. As a water soluble, fermented yeast extract, this product can be incorporated in virtually any aqueous system.

Benefits of FSS DermaPeptide Toning PF:

• Anti-Aging

• Tone & Elasticity

• Collagen Synthesis

• Wrinkle Reduction

Storage: Protected from direct light and humidity at a temperature of 50°-77°F (10°-25°C)
Shelf life: 12 months, properly stored, in sealed container.

This product should be added to a formulation at the recommended usage rate.